After defeating Owen Shaw and his crew and securing their amnesties, Dominic "Dom" Toretto, Brian O'Conner, and the rest of their team have returned to the United States to live normal lives again. Brian begins to accustom himself to life as a father, while Dom tries to help Letty regain her memories. Meanwhile, Owen's older brother, Deckard Shaw, breaks into the secure hospital the comatose Owen is being held in and swears vengeance against Dom, before breaking into Luke Hobbs' DSS office to extract profiles of Dom's crew. After revealing his identity, Shaw engages Hobbs in a fight, and escapes when he detonates a bomb that severely injures Hobbs. Dom later learns from his sister Mia that she is pregnant again and convinces her to tell Brian. However, a bomb, disguised in a package sent from Tokyo, explodes and destroys the Toretto house just seconds after Han, a member of their team, is killed by Shaw in Tokyo. Dom later visits Hobbs in hospital, where he learns that Shaw is a rogue special forces assassin seeking to avenge his brother. Dom then travels to Tokyo to claim Han's body, where he meets and races Sean Boswell, a friend of Han's, who gives him personal items found at Han's crash site.
Back at Han's funeral in Los Angeles, Dom notices a car observing and chases after the vehicle, driven by Shaw. Both prepare to fight, but Shaw slips away when a covert ops team arrives, led by a guy who calls himself Mr. Nobody. He says that he will assist Dom in stopping Shaw if he helps him obtain the God's Eye, a computer program that collectively uses digital devices such as cell phones and street cameras to track down a person, and save its creator, a hacker named Ramsey, from a mercenary named Jakande. Dom, Brian, Letty, Roman Pearce and Tej Parker then airdrop their cars over the Caucasus Mountains in Azerbaijan, ambush Jakande's convoy and rescue Ramsey. The team then heads to Abu Dhabi, where a billionaire has acquired the flash drive containing the God's Eye, and manages to steal it. With the God's Eye, the team manages to track down Shaw, who is waiting at a remote factory. Dom, Brian, Mr. Nobody and his team attempt to capture Shaw, but are ambushed by Jakande and his militants, and they are forced to flee while Jakande obtains the God's Eye. At his own request, Mr. Nobody is then left to be evacuated by helicopter. Left with no other choice, the team decides to return to Los Angeles to fight Shaw, Jakande and his men on their home turf.
While Jakande pursues Brian and the rest of the team with a stealth attack helicopter and drone, Ramsey attempts to hack into the God's Eye while sharing her mobile between their vehicles. Hobbs, seeing the team in trouble, breaks out of hospital and destroys the drone. Ramsey, with the help of Brian, then regains control of the God's Eye and shuts it down. Meanwhile, Dom and Shaw engage in a one-on-one brawl on a parking garage, before Jakande intervenes and attacks them both, and Shaw is defeated when part of the parking garage collapses under his feet. Dom then launches his vehicle at Jakande's helicopter, tossing a bag of grenades onto its skids, before injuring himself when his car lands and crashes. Hobbs then shoots the bag of grenades from ground level, destroying the helicopter. When Dom remains unconscious, the team fears that he is dead. As Letty cradles Dom's body in her arms, she reveals that she has regained her memories, and that she remembers their wedding, which happened in secret prior to her disappearance. Dom regains consciousness soon after, remarking, "It's about time".
Later, Shaw is taken into custody by Hobbs and locked away in a secret, high-security prison cell. Meanwhile, at a beach, Brian and Mia play with their son while Dom, Letty, Roman, Tej and Ramsey observe, appreciating their happiness and acknowledging that Brian is better off retired with his family. Dom silently leaves, and Brian catches up to him at a stop sign. As Dom remembers the times that he has had with Brian, they bid each other farewell and drive off in separate directions.
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